Steroid sparing immunomodulators

All but two episodes of rejection responded to . corticosteroid administration and the re-institution of oral prednisolone. One non-compliant patient experienced recurrent rejection as described above, and lost the graft. The second patient developed vascular rejection at 30 days, unresponsive to methylprednisolone and optimization of Tacrolimus and MMF. Plasma exchange followed by a course of anti-CD20 mAb (Rituximab; MabThera ® , Roche) led to clinical resolution with stable creatinine of 160 μmol/L at 12 months post-transplantation.

After the double-murder suicide, former wrestler Christopher Nowinski contacted Benoit's father, suggesting that years of trauma to his son's brain may have led to his actions. Tests were conducted on Benoit's brain by Julian Bailes, the head of neurosurgery at West Virginia University, and results showed that "Benoit's brain was so severely damaged it resembled the brain of an 85-year-old Alzheimer's patient." He was reported to have had an advanced form of dementia, similar to the brains of four retired NFL players who had suffered multiple concussions, sank into depression, and harmed themselves or others. Bailes and his colleagues concluded that repeated concussions can lead to dementia, which can contribute to severe behavioral problems.

Steroid sparing immunomodulators

steroid sparing immunomodulators

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