A study done by the Department of Sports Science at the University of Hull in Hull, UK has shown that nucleotides have significant impact on cortisol levels in saliva. Post exercise, the experimental nucleotide group had lower cortisol levels in their blood than the control or the placebo. Additionally, post supplement values of Immunoglobulin A were significantly higher than either the placebo or the control. The study concluded, "nucleotide supplementation blunts the response of the hormones associated with physiological stress." 
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Another adenine-based molecule is important in cellular signaling. When a hormone binds at a cell-surface receptor, it often promotes the production of cyclic AMP (cAMP) inside the cell. In cAMP, the phosphate group is joined to the 3 and 5 carbons of the ribose, forming a small ring structure. The molecular structures of the five nitrogenous bases. A nucleotide consists of a nitrogen-containing base, a 5-carbon sugar, and one or more phosphate groups. The sugar dipicted is ribose. Deoxyribose has an H instead of an OH in the boxed position. cAMP can activate or suppress various cell processes, thereby serving as an intracellular signal and messenger that responds to hormone binding.