Corticosteroid myopathy presents as weakness and wasting of the proximal limb and girdle muscles and is generally reversible following cessation of therapy.
Corticosteroids inhibit intestinal calcium absorption and increase urinary calcium excretion leading to bone resorption and bone loss. Bone loss of 3% over one year has been demonstrated with prednisolone 10 mg per day. Postmenopausal females are particularly at risk for loss of bone density. Sixteen percent of elderly patients treated with corticosteroids for 5 years may experience vertebral compression fractures. One author reported measurable bone loss over two years in women on concomitant therapy with prednisolone mg per day and tamoxifen. [ Ref ]
During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.
The Stanozolol hormone can be one of the few anabolic androgenic steroids women can use safely; while it is not the absolute mildest in nature for a woman it is up high on the list. Issues regarding the steroids hepatic nature as well as its effects on lipid profiles remain the same with women but the female athlete must also necessarily be aware of virilization. For the female athlete, the Winstrol side effects revolving around virilization will be the most concerning as such effects can destroy a womans femininity. Common virilization effects include a deepening of the vocal chords, body-hair growth and enlargement of the clitoris. The majority of women who supplement with the Stanozolol hormone, if they keep the dose low and use for very short periods will be fine. If you are a female Winstrol user and you begin to notice virilization symptoms simply discontinue use and you will be fine; nothing will change. It is when the symptoms are ignored, use is continued and the symptoms are allowed to set in that many women develop a problem; remember, man or woman responsible use is always your best friend.