Intra-articular corticosteroid injection arthritis

IT SHOULD BE EMPHASIZED THAT DOSAGE REQUIREMENTS ARE VARIABLE AND MUST BE INDIVIDUALIZED ON THE BASIS OF THE DISEASE UNDER TREATMENT AND THE RESPONSE OF THE PATIENT. After a favorable response is noted, the proper maintenance dosage should be determined by decreasing the initial drug dosage in small decrements at appropriate time intervals until the lowest dosage which will maintain an adequate clinical response is reached. Situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patient’s individual drug responsiveness, and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment. In this latter situation it may be necessary to increase the dosage of the corticosteroid for a period of time consistent with the patient’s condition. If after long-term therapy the drug is to be stopped, it is recommended that it be withdrawn gradually rather than abruptly.

Cartilaginous intra-articular bodies float freely within the synovial fluid, which they require for nutrition and growth.  Progressive enlargement and ossification occur with time.  If they remain free, they continue to grow larger and more calcified.  In severe cases, they may occupy the entire joint space or penetrate to adjacent tissues.  Alternately, they can deposit in the synovial lining, reestablish a blood supply, and become replaced by bone.  On occasion, synovial reattachment can lead to complete reabsorption of the cartilage fragment.

Intra-articular corticosteroid injection arthritis

intra-articular corticosteroid injection arthritis

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