Corticosteroides intraarticulares en equinos

Corticosteroids have been used as drug treatment for some time. Lewis Sarett of Merck & Co. was the first to synthesize cortisone, using a complicated 36-step process that started with deoxycholic acid, which was extracted from ox bile . [43] The low efficiency of converting deoxycholic acid into cortisone led to a cost of US $200 per gram. Russell Marker , at Syntex , discovered a much cheaper and more convenient starting material, diosgenin from wild Mexican yams . His conversion of diosgenin into progesterone by a four-step process now known as Marker degradation was an important step in mass production of all steroidal hormones, including cortisone and chemicals used in hormonal contraception . [44] In 1952, . Peterson and . Murray of Upjohn developed a process that used Rhizopus mold to oxidize progesterone into a compound that was readily converted to cortisone. [45] The ability to cheaply synthesize large quantities of cortisone from the diosgenin in yams resulted in a rapid drop in price to US $6 per gram, falling to $ per gram by 1980. Percy Julian's research also aided progress in the field. [46] The exact nature of cortisone's anti-inflammatory action remained a mystery for years after, however, until the leukocyte adhesion cascade and the role of phospholipase A2 in the production of prostaglandins and leukotrienes was fully understood in the early 1980s.

A atividade benéfica da vitamina D3 pode ser reforçada por outras substâncias, incluindo determinadas vitaminas . Se a vitamina D facilita a absorção de cálcio pelo intestino, pelo seu lado, a vitamina K intervém para distribuir o cálcio no organismo. Tendo em conta as suas atividades complementares para a mineralização óssea, estas duas vitaminas encontram-se agora associadas na formulação MK-7 + D3 . Os efeitos benéficos e protetores deste suplemento nutricional tornam-no particularmente recomendado às pessoas idosas, às que sofrem de osteoporose e às pessoas que apresentam riscos hemorrágicos ou riscos de doenças cardiovasculares. Para reforçar os efeitos protetores destas vitaminas, é igualmente possível capitalizar sobre a atividade antioxidante da coenzima Q10 . Esta substância é considerada um nutriente-chave para a proteção de vários órgãos vitais, entre os quais o coração e o cérebro.

Corticosteroides intraarticulares en equinos

corticosteroides intraarticulares en equinos

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