Stanozolol can stimulate the production of prostaglandin E2 and the matrix metalloproteases collegenase and stromelysin in skin fibroblasts. It has been found to inhibit growth factor stimulated DNA synthesis and fibroblasts. Winstrol has substantial fibrinolytic properties, and has been effective in the treatment of urticaria, Raynaud’s phenomenon, cryptofibrinogenemia, and lipodermatosclerosis. Stanozolol has also effected cures of osteonecrosis in cases resistant to all other therapy. Stanozolol has been used successfully in treatment of AIDS wasting syndrome.